neglected diseases

Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity

A common strategy to identify new antiparasitic agents is the targeting of proteases, due to their essential contributions to parasite growth and development. Metacaspases (MCAs) are cysteine proteases present in fungi, protozoa, and plants. These …

TDR Targets 6: Driving drug discovery for human pathogens through intensive chemogenomic data integration

TDR Targets, a chemogenomics resource for Neglected Diseases

A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases

Neglected tropical diseases are human infectious diseases that are often associated with poverty. Historically, lack of interest from the pharmaceutical industry resulted in the lack of good drugs to combat the majority of the pathogens that cause …

Neglected Tropical Diseases in the Post-Genomic Era

Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets

TDR Targets: A Chemogenomics Resource for Neglected Diseases

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

Genomic-scale prioritization of drug targets: the TDR Targets database