The Trypanosomatics Laboratory

Working on data integration to discover new drugs and diagnostics for human pathogens.


Our laboratory is interested in the study of human pathogens, particularly trypanosomes and also others that cause so-called Neglected Tropical Diseases.

We develop computational tools and produce (and re-use) large data sets to formulate and guide our research hypotheses in the quest for new drugs and diagnostics. Smart and intensive data integration, data mining, and high-throughput assays and experiments are at the core of our research activities.

In particular, we have a special interest in the study of trypanosomes such as Trypanosoma cruzi (causative of Chagas disease).

Wellcome to our electronic home in the web. Feel free to browse and poke around.

Recent Posts

Beca ANPCyT 2022

Búsqueda de candidata/o a Beca Doctoral

Orientada a graduados en biotecnología, biología, bioquímica, o relacionadas.

Estamos buscando …

Alanine Scan for known Chagas antigens, November 2019 update

Chagas Disease is a major health problem for which no vaccine for public health interventions are yet available. Diagnosis is essential …

Serodiscordance and borderline serology, November 2019 update

Diagnosis of chronic Chagas Disease is currently based on serological techniques. Although available diagnostic tests give satisfactory …

Recent & Upcoming Talks

Find us at these events and meetings

Development of a Chagas Disease Antigen and Epitope Atlas using massively parallel serological assays

How we used peptide arrays to discover new antigens and epitopes and map the presence of antibodies in patients

2022 SAP A drug-target prioritization strategy using the TDR Targets database leads to novel trypanocidal compounds with known active functional groups

Only got two mins? The drug repurposing approach to drug discovery for neglected diseases has shown to be effective to find potential …

The serological antibody repertoire in Chagas Disease

Towards a comprehensive description of the specificities of individual antibody repertoires in Chagas Disease

From yeast to tryps: repurposing strategies through conserved druggable modules

Computational repositioning of bioactive compounds from large chemogenomic screens: identification of conserved druggable modules …




Development of new diagnostic tools for infectious diseases

High-throughput screening of trypanocidal agents

Identification and repurposing of bioactive compounds for Chagas disease: combining chemogenomics with high-throughput phenotypic …


Data integration for target prioritization and drug discovery or repurposing

Genetic Diversity

A map of genetic variation for Trypanosoma cruzi and its use on strain typing applications


Data integration for target prioritization and drug discovery or repurposing

Congenital Chagas disease diagnosis

Antigens discovery for congenital Chagas disease, mapping and validation of epitopes for newborns serological diagnosis kit.

Immunomics of Infectious Diseases

High-throuput screening and data integration for diagnostics tool development

Yeast-to-Tryp Drug Repurposing

Exploiting conserved druggable modules between yeasts and trypanosomes for drug repurposing

Recent Publications by lab members

From pre-prints to final publications, it’s all here

Quickly discover relevant content by filtering publications.

Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity

A common strategy to identify new antiparasitic agents is the targeting of proteases, due to their essential contributions to parasite …

Target-based screening of the Chagas box: setting up enzymatic assays to discover specific inhibitors across bioactive compounds.

Chagas disease is a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. The disease is endemic in Latin …

This is Us

The people behind the tryps



Fernán Agüero

Principal Investigator, Assistant Professor

Diagnostics, Drug Discovery, Bioinformatics, Genomics, Neglected Diseases, Trypanosomes


Emir Salas Sarduy

Associate Investigator

Chemogenomics, Biochemistry, High-Throughput Screenings

Grad Students


Alejandro Ricci

PhD Student

Chagas Disease, Bioinformatics, Neural Networks


Armando E.Fernandez

PhD Student

Biochemistry of Proteins, Molecular Biology, Chagas Diseases, Recombinant Proteins


Leonel Bracco

PhD Student

Diagnostics, Bioinformatics, Neglected Diseases, Congenital Chagas, Trypanosomes


Lionel Urán Landaburu

PhD Student

Chemogenomics, Neglected diseases, Drug Discovery


Mercedes Didier Garnham

PhD Student

Chemogenomics, Neglected Diseases, Drug Discovery



Ramiro Quinteros

Undergrad Student (BSc Thesis)

Bioinformatics, Chagas Disease, Data Analysis


Sebastián Jinich

Undergrad Student (BSc Thesis)

Bioinformatics, Drug Discovery, Neglected diseases, Computer Science

Past Lab Members


Alejandro A Ackermann

Former Lab Member (2005 – 2012)


Leonardo G Panunzi

Former Lab Member (2007 – 2014)


María Paula Magariños

Former Lab Member (2009 – 2014)


Raúl O Cosentino

Former Lab Member (2007 – 2014)


Santiago J Carmona

Former Lab Member (2007 – 2015)




A Trypanosome in the Shell