Immunomics of Infectious Diseases
Unraveling the antibody diversity in Chagas Disease using antigen microarrays.
During an infection, the immune system produces antibodies against pathogens. With time, the immune repertoires of infected individuals become specific to the history of infections and thus represent a rich source of diagnostic markers. We are using high-density peptide arrays to examine the human antibody repertoires developed by Chagas Disease patients. The aim is to uncover the diversity of recognized antigens and build an atlas of antigens and epitopes for Chagas Disease.
PhD Fellow and teaching assistant.
Former Trypanosomatics Lab Member (2007 – 2015)
Present address: Ludwig Center for Cancer Research, University of Lausanne
Principal Investigator, Assistant Professor
Using and generating data to guide discovery of new drugs and diagnostics.
- Towards High-throughput Immunomics for Infectious Diseases: Use of Next-generation Peptide Microarrays for Rapid Discovery and Mapping of Antigenic Determinants
- Diagnostic peptide discovery: prioritization of pathogen diagnostic markers using multiple features
- Mapping antigenic motifs in the trypomastigote small surface antigen from Trypanosoma cruzi
- Congenital Chagas disease diagnosis
- Neglected Tropical Diseases in the Post-Genomic Era