A common strategy to identify new antiparasitic agents is the targeting of proteases, due to their essential contributions to parasite growth and development. Metacaspases (MCAs) are cysteine proteases present in fungi, protozoa, and plants. These …
Towards a comprehensive description of the specificities of individual antibody repertoires in Chagas Disease
Chagas disease is a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. The disease is endemic in Latin America with about 6 million people infected and many more being at risk. Only two drugs are available for treatment, …
How we use this technology to discover new antigens and epitopes in matched mother-newborn samples
Chagas disease, caused by the parasite Trypanosoma cruzi, is a life-long and debilitating illness of major significance throughout Latin America, and an emergent threat to global public health. Diagnostic tests are key tools to support disease …
High-throuput screening and data integration for diagnostics tool development
Setting the stage for high-throughput immunomics in Chagas Disease