Chemogenomics
Genomics based drug discovery, by @leitouran
This is a major research line in the Trypanosomatics Lab, which gives rise to a wide variety of projects:
All these projects have in common the ultimate goal of finding new treatments (drugs) for infectious diseases.
Depending on the approach (computational vs hybrid vs experimental), we may target a large number of human pathogens (as in TDR Targets) or may concentrate only on Chagas Disease (American Trypanosomiasis, caused by Trypanosoma cruzi) or on Sleeping Sickness (Human African Trypanosomiasis, HAT, caused by Trypanosoma brucei).
Please check the pages for these subprojects for more information.
Lionel Urán Landaburu
Former Lab Member (2016 – 2023)
PhD Fellow, teacher and science divulgation enthusiast.
Mercedes Didier Garnham
PhD Student
Fernán Agüero
Principal Investigator, Assistant Professor
Using and generating data to guide discovery of new drugs and diagnostics.
Publications
Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery
n this review, we discuss how genomics is being used for drug discovery in trypanosomatids.
TDR Targets 6: Driving drug discovery for human pathogens through intensive chemogenomic data integration
TDR Targets, a chemogenomics resource for Neglected Diseases
Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes
American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid …
A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases
Neglected tropical diseases are human infectious diseases that are often associated with poverty. Historically, lack of interest from …
Identification of attractive drug targets in neglected-disease pathogens using an in silico approach
Talks
2022 SAP A drug-target prioritization strategy using the TDR Targets database leads to novel trypanocidal compounds with known active functional groups
Only got two mins? The drug repurposing approach to drug discovery for neglected diseases has shown to be effective to find potential …
From yeast to tryps: repurposing strategies through conserved druggable modules
Computational repositioning of bioactive compounds from large chemogenomic screens: identification of conserved druggable modules …
TDR Targets: driving drug discovery for human pathogens through intensive chemogenomic data integration
Mind the gap: Bridging the knowledge rift between model organisms and pathogens causing neglected diseases