drug-discovery

From yeast to tryps: repurposing strategies through conserved druggable modules

Computational repositioning of bioactive compounds from large chemogenomic screens: identification of conserved druggable modules between yeasts and trypanosomes

TDR Targets: driving drug discovery for human pathogens through intensive chemogenomic data integration

Mind the gap: Bridging the knowledge rift between model organisms and pathogens causing neglected diseases

TDR Targets 6: Driving drug discovery for human pathogens through intensive chemogenomic data integration

TDR Targets, a chemogenomics resource for Neglected Diseases

High-throughput screening of trypanocidal agents

Identification and repurposing of bioactive compounds for Chagas disease: combining chemogenomics with high-throughput phenotypic screening

tdrtargets

Data integration for target prioritization and drug discovery or repurposing

Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes

Identification of the first inhibitors and chemical tools for the M32 family of carboxypeptidases

TDR Targets: integrated chemogenomic mining of pathogen genomes for drug discovery

A recap on updates & updagrades for TDR Targets chemogenomics resource to aid on drug discovery, repurposing and develeopment for neglected diseases

Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes

American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox and benznidazole, two drugs …

Chemogenomics

Data integration for target prioritization and drug discovery or repurposing

Yeast-to-Tryp Drug Repurposing

Exploiting conserved druggable modules between yeasts and trypanosomes for drug repurposing