The volume of biological, chemical and functional data deposited in the public domain is growing rapidly, thanks to next generation sequencing, and highly-automated screening technologies. However, there is still a large data imbalance between model, well-funded organisms and pathogens causing neglected diseases (NDs). We developed a chemogenomics resource, (TDR Targets, https://tdrtargets.org), that aims to organize and integrate heterogeneous large datasets with a focus on drug discovery for human pathogens. The database also hosts chemical and genomic data from other organisms to leverage data for comparative and inference-based queries. One of the major impacts of TDR Targets is to facilitate target and chemical prioritizations by allowing users to formulate complex queries across diverse query spaces.
- Yeast-to-Tryp Drug Repurposing
- A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases
- Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes
- Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets