drug-discovery

Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes

American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox and benznidazole, two drugs …

Chemogenomics

Data integration for target prioritization and drug discovery or repurposing

Yeast-to-Tryp Drug Repurposing

Exploiting conserved druggable modules between yeasts and trypanosomes for drug repurposing

A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases

Neglected tropical diseases are human infectious diseases that are often associated with poverty. Historically, lack of interest from the pharmaceutical industry resulted in the lack of good drugs to combat the majority of the pathogens that cause …

Neglected Tropical Diseases in the Post-Genomic Era

Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets

TDR Targets: A Chemogenomics Resource for Neglected Diseases

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

Genomic-scale prioritization of drug targets: the TDR Targets database